WARHEAD HUNTER PROTOCOL

Provide a target label + an RCSB search phrase. FASTA is optional but improves specificity when matching proteins.

START HERE — WHAT THIS TOOL SEARCHES

Warhead Hunter searches RCSB for ligand-bound structures matching your phrase, then maps solvent exposure around their ligands. It does not search a target name alone: the query should describe a protein plus a bound ligand, inhibitor, or covalent state.

1. Name the targetA short label for your results, e.g. CRBN.

2. Describe the structureUse a searchable RCSB phrase, e.g. cereblon pomalidomide bound.

3. Add FASTA if neededRecommended for broad names or protein families; then launch the scan.

Not sure what to type? Load a complete example

These fill both required fields with a working search pattern. You can edit them before launching.

Target Identifier

Step 1: a short name for this run only. This field does not control the RCSB search.

CRBN

HIV-1 Protease

DYRK1A

RCSB Search Query

Step 2: this controls the RCSB search. Include the protein plus “bound”, a ligand/inhibitor name, or “covalent”. Avoid a target name by itself.

cereblon pomalidomide bound

HIV-1 protease inhibitor bound

DYRK1A inhibitor bound

Sequence (FASTA) — Optional

Recommended when your search term is broad. If you paste FASTA, include the header line starting with “>”.

Review the target and search phrase, then initiate the scan. Need help finding a PDB first? Use RCSB Target Scout.