Warhead Hunter PROTAC Target Module

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Checking molecular artifacts

Initializing results command center

Preparing the first usable ligand.

WARHEAD COMMAND CENTER: b2ba2abd · HSP70

GOK

6hsk (CHAIN A)

72.4% EXPOSED

SASA atoms

21 / 29

% buried

27.6%

SASA

219.1Å²

GOK

6hsk (CHAIN B)

72.4% EXPOSED

SASA atoms

21 / 29

% buried

27.6%

SASA

223.0Å²

3JE

4r5g (CHAIN B)

66.7% EXPOSED

SASA atoms

18 / 27

% buried

33.3%

SASA

243.9Å²

H5V

8d1p (CHAIN A)

65.0% EXPOSED

SASA atoms

26 / 40

% buried

35.0%

SASA

382.0Å²

DIO

5vi6 (CHAIN A)

53.6% EXPOSED

SASA atoms

15 / 28

% buried

46.4%

SASA

142.5Å²

3P1

3ldp (CHAIN A)

45.2% EXPOSED

SASA atoms

14 / 31

% buried

54.8%

SASA

137.3Å²

3FD

6cz1 (CHAIN A)

44.7% EXPOSED

SASA atoms

17 / 38

% buried

55.3%

SASA

171.1Å²

3FD

8d24 (CHAIN A)

44.7% EXPOSED

SASA atoms

17 / 38

% buried

55.3%

SASA

112.8Å²

TO1

8d1s (CHAIN A)

42.9% EXPOSED

SASA atoms

9 / 21

% buried

57.1%

SASA

82.6Å²

3FD

6cz1 (CHAIN B)

39.5% EXPOSED

SASA atoms

15 / 38

% buried

60.5%

SASA

161.9Å²

HFY

8d1w (CHAIN A)

39.3% EXPOSED

SASA atoms

11 / 28

% buried

60.7%

SASA

119.2Å²

7DT

5exw (CHAIN A)

38.7% EXPOSED

SASA atoms

12 / 31

% buried

61.3%

SASA

52.1Å²

7DT

5exw (CHAIN B)

38.7% EXPOSED

SASA atoms

12 / 31

% buried

61.3%

SASA

53.5Å²

DAT

5f0x (CHAIN B)

38.5% EXPOSED

SASA atoms

10 / 26

% buried

61.5%

SASA

51.8Å²

HFY

6dws (CHAIN A)

38.3% EXPOSED

SASA atoms

18 / 47

% buried

61.7%

SASA

131.8Å²

HFY

6dws (CHAIN B)

38.3% EXPOSED

SASA atoms

18 / 47

% buried

61.7%

SASA

135.1Å²

7DD

5ex5 (CHAIN A)

37.0% EXPOSED

SASA atoms

10 / 27

% buried

63.0%

SASA

52.2Å²

7DD

5ex5 (CHAIN B)

37.0% EXPOSED

SASA atoms

10 / 27

% buried

63.0%

SASA

53.2Å²

3P1

3ldp (CHAIN B)

35.5% EXPOSED

SASA atoms

11 / 31

% buried

64.5%

SASA

113.3Å²

Q3V

8d1y (CHAIN A)

32.0% EXPOSED

SASA atoms

8 / 25

% buried

68.0%

SASA

99.5Å²

Q8L

8d22 (CHAIN A)

31.0% EXPOSED

SASA atoms

9 / 29

% buried

69.0%

SASA

144.3Å²

3BH

6dfm (CHAIN A)

30.0% EXPOSED

SASA atoms

6 / 20

% buried

70.0%

SASA

30.5Å²

3BH

6dfm (CHAIN B)

30.0% EXPOSED

SASA atoms

6 / 20

% buried

70.0%

SASA

27.0Å²

3BH

8d1q (CHAIN A)

30.0% EXPOSED

SASA atoms

6 / 20

% buried

70.0%

SASA

38.0Å²

MTA

8d20 (CHAIN A)

25.0% EXPOSED

SASA atoms

5 / 20

% buried

75.0%

SASA

38.3Å²

SAH

4lec (CHAIN B)

23.1% EXPOSED

SASA atoms

6 / 26

% buried

76.9%

SASA

12.3Å²

GBA

6dfo (CHAIN A)

20.0% EXPOSED

SASA atoms

4 / 20

% buried

80.0%

SASA

25.0Å²

GBA

6dfo (CHAIN B)

20.0% EXPOSED

SASA atoms

4 / 20

% buried

80.0%

SASA

25.0Å²

H5V

6do2 (CHAIN A)

19.4% EXPOSED

SASA atoms

7 / 36

% buried

80.6%

SASA

23.4Å²

SAH

4lec (CHAIN A)

15.4% EXPOSED

SASA atoms

4 / 26

% buried

84.6%

SASA

10.1Å²

H5V

6do2 (CHAIN B)

13.9% EXPOSED

SASA atoms

5 / 36

% buried

86.1%

SASA

22.8Å²

SJT

7vpx (CHAIN 6)

0.0% EXPOSED

SASA atoms

31 / 37

% buried

100.0%

SASA

533.0Å²

2D LIGAND MAP

GREEN (15–24 Å²)

YELLOW (24–34 Å²)

RED (≥34 Å²)

Atoms w/ SASA below 15 Å² are not highlighted

Highlighted atoms show linkable attachment sites

CHEMICAL PROPERTIES

QED: —

poor moderate good

Drug-likeness filters

Drug-likeness heuristics (informative, not absolute)